Effect persists between rooms while the time period is active, Speed Down - Reduces your speed stat by -0.12, Speed Up - Increases your speed stat by +0.15, Tears Down - Reduces your tears stat by -0.28, Tears Up - Increases your tears stat by 0.35, Telepills - Teleports you to a random room when used. Counts as 1 of 3 book items needed towards the Bookworm transformation. A new study out of Sweden has found that those who contract COVID-19 have an increased risk of certain types of blood clots, which can be fatal, up to six months after infection. Interestingly enough, the beam will look like a G clef symbol. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, Spoon Bender will give them a homing effect, and status effects like fear/poison will spread onto all enemies the electricity chains to, Tears which fall naturally to the floor at max range do not generate sparks, It's possible to fire tears at a wall to create electricity that damages enemies on the other side of the wall, *, silver, metal, grey, gray, blue, jacob ladder, jacobs ladder, Each tear now has a small chance to be a spectral blue flame instead, which deals damage to enemies that come in contact with it, The fire will remain in place and shrink in size when deals damage to something. When you take the reverse path back up to Home, the trinket will turn into Cracked Key in the same floor/room you dropped it before. Items Counts as 1 of 3 poop items needed towards the Oh Crap transformation. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. Multi-shot effects add 1 bomb to the barrage, up to 21 bombs. Blood Clot / Chemical Peel / The Peeper: 50% chance to apply the flat damage up/damage increase with each shot. Pickup Quote Rooms Brimstone is a passive item. Using Sumptorium as her will then cause all Clots to be consumed and return your hearts back to you. BFFS! Can only happen once per room, Visually this is almost identical to the Guardian Angel item, but without a face, UNLOCK: Unlock this item by beating Blue Womb (Hush) with The Lost, A white orbiting fly which deals 3 contact damage per tick to enemies, This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone, Item Pool: Item Room, Greed Mode Item Room, Key Beggar. Modes ?, Satan and The Lamb as Tainted Bethany, Taking damage gives you a chance to spawn a flame orbital, similar to the ones created by Book of Virtues, Entering an Angel Room gives you +5 flame orbitals. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) This room isn't part of the actual floor, and leaving it returns you to where you teleported from, The boss isn't necessarily from the current floor - e.g. Your blood naturally clots so you don't lose too much blood if you are injured. ?, Satan and The Lamb as Tainted Eden, Each brand new room, this trinket has a chance to transform into a copy of a random passive item, which gives you the effect for the duration of this room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eden, Gives a small chance to spawn a friendly Bony when clearing a room, which will throw bones at enemies until it takes enough damage to die, Can be either the regular white Bony or the black variant, UNLOCK: Unlock this trinket by defeating Isaac, ?? Challenges . The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Poison) rapidly due to how often it hits, REPENTANCE - The -65% Damage down has been removed! If a devil deal was already taken this run, it spawns 2 soul hearts and 1 Angel Room item instead. Seeds According to the Bible, "Brimstone", which is possibly the ancient name for sulfur, evokes the acrid odor of volcanic activity. white, square, When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations), REPENTANCE - Book of Secrets now avoids giving mapping effects that the player already has. Seeds with Brimstone you get 4 lasers, Counts as 1 of 3 spider items needed towards the Spider Baby transformation, * item room, treasure room, item room pool, green, black, +2 Damage Up for tears fired from Isaac's left eye, If playing as Cain or you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage, * item room, treasure room, item room pool, poison, green, brown, bottle, jar, danger, Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies, Damage from Isaac's left eye deal roughly +35% damage, * item room, treasure room, item room pool, red, white, When you take damage, this item recharges one room's worth of charge to your spacebar item, For example, with the D6 you would need to take damage 6 times to fully recharge it, * angel room pool, god room pool, angel room item, shop room pool, shop item pool, Returning back through the mirror door returns you back to normal again. Speed Up will be +0.3 instead of +0.15. Poison, Homing, Prize Bombs), In Antibirth this was called Enigma Bombs, Spawns a red worm familiar that chases enemies nearby around the room and deals 2 contact damage per tick. This video showcases all blood clot familiar variants that can be created with the Sumptorium item in The Binding of Isaac Repentance. Basement 1, Cathedral, Sheol etc. the lost item pool, red, beads, grey, gray, cross, necklace, An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick, Exclusively drops from one of the horsemen bosses, 2 cubes of meat transform the orbital into a meat head which fires blood tears which deal 3.5 damage each, 3 cubes of meat transform it into a meat boy familiar that walks around and deals 3.5 contact damage per tick to enemies, 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead, Any further cubes of meat past 4 will start the cycle again, UNLOCK: Unlock this item by beating Mom for the first time, Has a very small chance to drop after destroying one of the pots that appear in the Basement and Cellar floors, Has a chance to drop from the Super Greed miniboss fight, UNLOCK: Unlock this item by beating Mom's Heart 8 times, Item Pool: Devil Room, Gold Chest, Super Greed Miniboss. A small clot friend will hug Isaac, following his exact movements . * item room, treasure room, item room pool, white, purple, Gives Isaac the ability to fly and spectral tears, * devil pool, devil room pool, devil deal, red, crescent, moon, drop, black, Creates 5 beams of light from the sky that deal damage equal to your tear damage + 20 to any enemies which come into contact with them, The beams have a high chance to spawn on top of enemies where possible, * item room, treasure room, item room pool, feather, white, arrow, Upon death, you respawn in the previous room as Blue Baby with three Soul hearts, This is a one time use item and all new heart containers will be soul hearts, Can be used to unlock some of Blue Baby's secrets before having the character available, * item room, treasure room, item room pool, black, grey, gray, extra life, egypt, grey, gray, Upon taking damage, you have a 20% chance to gain an invulnerability shield for 7 seconds, The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time, UNLOCK: Unlock this item by beating the Chest with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, These only appear if not all runes have been unlocked yet. UNLOCK: Unlock this item by getting all hard mode completion marks for the 17 non-tainted characters, Combine with Knife Piece 2 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Downpour/Dross II, you will find a white flame somewhere, and a room with a mirror in it. +4 damage from Curved Horn instead of 2, -4 Tear Delay from Cancer instead of 2), Item Pool: Shop, Greed Mode Shop, Mom's Chest, Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Activating Sumptorium restores Tainted Eve's health (if possible) and axes living clots (though not all of them? "I'm seeing red" Cannot be rerolled by 4-pip dice rooms and Spindown Dice, Clearing a room will spawn an extra reward, however only one can be picked up - the other one will disappear, UNLOCK: Unlock this item by defeating the The Beast as Isaac, Every half red heart you pick up gives a small but permanent stat increase, Randomly picks between +0.10 Damage Up, +0.05 Tears Up, +0.15 Range Up, +0.02 Speed Up, +0.1 Luck Up, +0.02 Shot Speed Up per half red heart, UNLOCK: Unlock this item by defeating The Beast as Magdalene, This item causes Devil deals to cost money instead of hearts, and shop items to cost hearts instead of money, Shop items cost heart containers, and pickups have spikes around them, The Devil deal conversion rate is 1 heart container to 15 coins, Devil deal items can be on discount similar to the shop, making it 1 heart container = 7 coins instead, UNLOCK: Unlock this item by defeating The Beast as Cain, Every time you enter a devil room and choose not to take an item, you get +1 Damage Up upon entering the next floor, The effect is shown via a cross above Isaac's head. 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